Like Parent, Like Child: Inheritance of Effector CD8+ T Cell Traits

Aging promotes acquisition of naive-like CD8+ memory T cell traits and enhanced functionalities.

Protective T cell memory is an acquired trait that is contingent upon the preservation of its constituents and therefore vulnerable to the potentially deleterious effects of organismal aging. Here, however, we have found that long-term T cell memory in a natural murine host-pathogen system can substantially improve over time. Comprehensive molecular, phenotypic, and functional profiling of agin...

Notch controls effector CD8+ T cell differentiation

CD8+ T cell recognition of foreign antigen induces the expansion of the few T cells bearing an appropriate T cell receptor and the acquisition of effector functions. These effector CD8+ T (Te) cells eliminate the pathogen by secretion of cytokines or by direct cytotoxicity. Following this initial clonal expansion, 90-95% of the Te cells die while the few others further differentiate into memory...

Self-Antigen Prevents CD8 T Cell Effector

Like parent, like child: child food and beverage choices during role playing.

OBJECTIVE To examine food and beverage choices of preschool-aged children. DESIGN Semistructured observational study. While pretending to be adults during a role-play scenario, children selected food and beverage items from a miniature grocery store stocked with 73 different products, of which 47 foods and beverages were examined in this analysis. Parents self-reported how frequently they pur...

Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering.

To better understand how innate and adaptive immune responses interact with each other, we combined 4-1BB T cell costimulation with specific adjuvants to determine whether these treatments would influence specific T cell expansion and function in vivo. In the presence of 4-1BB ligation and Toll-like receptor 3 (TLR)3 and/or TLR4 triggering, CD8 T cell clonal expansion and survival was augmented...